Cinebench is a fair assessment of graphic performance in OpenGL and here it confirms the performance drop.
There is little potential performance difference unless more than one graphics card is used. The M6E with its lane switch can support two or more cards at PCIE3 x16 bandwidth. With two cards, the M6F has to split the 16 native lanes of the CPU to x8/x8. With one video card, you should not see any difference,
For your performance drop, I can suggest that you look in BIOS Advanced tab. Several of the areas under there have to do with system agent and PCIE settings. Check that the video card's slot is running at gen 3 speed and x16 lanes. Aggressive power saving should be disabled for max performance. If you're not using it, the CPU integrated graphics and iGPU multimonitor should be disabled.
Similarly, check the power options in Windows Control Panel. You may get better results with a performance setting.
Hope these help
Jeff