Intel wants the Vcore to droop at higher load in order to stay within the Thermal Design Profile (TDP) of the chip and to reduce the chances of thermal throttling at the highest loads. They call this a load line droop. With good cooling and a ROG motherboard, we are less concerned with the thermal and power limits. Accordingly, we can use less droop - a load line compensation (LLC), take higher power consumption at high loads and the CPU temperature still stays in bounds.
When cooling is very good - custom water loop or very efficient all-in-one water - LLC can be set so Vcore actually rises under load. That way the core gets more voltage just when it is susceptible to crash, freeze or bluescreen. With my R4E, Vcore rises slightly at load - about .02v - with the Ultra High setting I use for most benching.
The Extreme setting makes Vcore rise more with load. That's where the danger is. Voltage, power at high load and therefore temperature can increase beyond what is planned for. With extreme cooling - phase change, dry ice, LN2 - temperatures stay in bounds and extreme overclockers can get their scores.
You don't say what cooling is used and I have mentioned where and why that is important. With water cooling, I consider Ultra High safe for 24/7 use. If 24/7 use sees peak load only rarely, there should be no harm at all. If there is a lot of benchmarking with an overclocked and stressed CPU, see to the cooling first.
Jeff