Hi all, these thread is link with that one
https://rog.asus.com/forum/showthread.php?100600-Single-core-100-CPU-high-interrupts-on-ACPI and also with the reddit you can find in the first page of the link.
A lot of people suffer ACPI interrupt and core 2 utilization 100%, window latency, in game fps drop when tbt3, thunderbolt 3 is active in bios.
Since a long time nobody have a constructive answer from asus, the last was they can't replicate...
These thread is here to show how many people suffer this issue to force an asus answer maybe one day (some of them wait since the release of the board).
Just put a +1 if you have these issue, thank you all.