Ok , I Tried The Driver Asus (Version 6.0.1.8746) , Gives Me Your Issue Low Audio In Some Media , Reinstalled My Own Audio Driver Asus 6.0.1.7035 {G30AB] And Asus Version 6.0.1.7586 {G11CD} , No Issue , , Yes The PCs And Asus Laptops I Have Are Different From Your B450-F , But The Audio Chips Are More Or Less The Same , I Use Only Asus Realtek Drivers , No Other Audio Enhancements Like Sonic Studio ect Non Of That Crap And No Over Clocking , , Have You Tried The First W10 Driver For Your Motherboard Version 6.0.1.8339 ? , One Thing I Do Know Is Audio , Audio Is Weakest Link In W10 , I Also Have A Sound Card , I Use It Only For Editing
One More Question Are You Using Sonic Studio III If So Can You Only Use The Realtek Diver Disable Sonic Studio ? See What Happens ? Set Up The Realtek HD Manager For 5.1 ?
Should You Install An Audio Driver Make A Restore Point In Case You Want To Go Back To Original Driver