Which KVM hypervisor? Just asking in case you're not using this. Can never tell with Fedora users, lol.
Are the (Win10) GTX1080, (Win10) RX480, and (Fedora) GT720 each outputting on separate monitors?
I don't understand your need for discrete USB cards ... unless each of your (three) operating systems runs its own array of USB hardware. Or your mobo's dozen USB ports just aren't enough, lol. I thought the KVM software could partition the USB controllers/ports (just as it does with main memory and other hardware resources). I might be wrong.
When you apply a USB device to a VM you can't remove it or add a new one while the VM is running. If you pass the whole USB pci card to the VM you can plug and unplug devices on the fly. Also when using USB headsets you can get cracking sounds.
550 bucks for the motherboard, doesn't work and can't even get a reply.... ****.
Key feature "Virtualization"
32 threads and virtualization isn't a use case? What would be the use case? Some video editing? Why make a gaming motherboard if you can't use all the core. I should be able to run 4 gaming boxes off of this machine.