https://rog.asus.com/articles/gallery/what-is-rog-keybot/KeyBot is primarily supposed to just add programmable macro functionality.
But I do recognize that KeyBot is an added in-line hardware component, running its own little logic, so it is indeed conceivable it creates quirks or bugs or interference with normal keyboard functions.
Some keyboards are not perfectly compatible any more (they use old scan sets), but this is an increasingly rare issue and the chance of you using two such keyboards is slim indeed.
The computer can wakeup from sleep/hibernate with a keypress (or mouseclick) on any USB port. There are BIOS settings to configure these parameters. Many keyboards also include a sleep/wake button (which I despise, personally, but it's still there). So this "added" wake/sleep functionality marketed on KeyBot is basically redundant, if you don't use the KeyBot macro functions then maybe it's better to not use it at all.
Have you compared the wake behaviour with the keyboard plugged into the KeyBot USB port vs other USB ports?
Have you compared the wake behaviour with Legacy (keyboard) USB functions enabled/disabled in BIOS?
Sleep/wake behaviour seems to always be a touchy thing on feature-rich ASUS motherboards. And general Win10 faults/instabilities (over time) certainly don't help simplify things, although you can go through your Windows Power Settings and your USB Power Settings (in Device Manager > Properties > Advanced) to confirm that the USB port/keyboard itself remains powered on when the machine powers down.
"All opinions are not equal. Some are a very great deal more robust, sophisticated and well supported in logic and argument than others." - Douglas Adams
[/Korth]