1. in bios enable S4
2. enable numlock on start, again in bios, usually default
3. read Z-270 overclock guide on these forums, list all your system specs, then ask more specific questions but for most daily use default settings are more than enough and fully stable
4. purchase a drive bay USB 3.0 panel
5. I don't use them myself
6. uninstall all sound drivers, download the latest and reinstall, I am not sure of these settings