I'm also experiencing random lockups and reboots on a brand new Maximus VIII Gene with fresh install of Windows 10. This mostly happens during gaming. I have the latest bios installed. Event viewer shows Event ID 56 a second before the crash. Every single time. Seems to be a problem with the Z170 platform. If ASUS doesn't fix it with a bios update, I'm selling this motherboard and cpu and moving over to the X99 platform.