Have two each 64bit systems connected to a router connected to a cable mode and a switch, two each WD MY Book external drives, a blu-ray player and an UHD 4K 70" flatscreen TV . The TV, Blu-Ray player and the two WD externals are all connected to the systems using the router and the switch - have had no problems with installing Win10 TP with the external drives powered up during the install and reboots. I'm assuming here the external drives, being connected to the router, are isolated from the install and reboot process and are not giving me any problems. (Obviously I can't prove this - just passing on the info.)
Lian-Li PC-A77F Full Tower case
PC Power & Cooling Turbo-Cool 1200 ATX12V & EPS12V PSU
ASUS Rampage IV Extreme LGA 2011 X79
Intel Core i7-3960X 3.31 LGA 2011 CPU
Intel RTS2011LC Liquid Cooling Solution
Kingston KHX24C11T3K4/32X (quad 32Gb memory kit) 2 each
ASUS Radeon HD7970 DirectCUII 3Gb GDDR5 PCIe 3.0 x16 Video Card (two in CrossfireX Mode)
Western Digital Cavier Black 2Tb SATA III 6.0GB/S
OCZ Technologies Vertex 4 SATAIII 6Gb/s 512Gb SSD