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Turn off M.2?

Level 8
Hi All,
Is there a way I can turn my M.2 drive off, I want to install an OS on another drive and it will ruin the OS I have on the M.2 if it see's it.

It's not as simple as just removing the M.2 as my graphics card is blocking me from doing so, such a pain.


Level 8
Good point, i noticed in the Bios sometime back that it cannot be disabled. Auto/M.2 is all your offered, which is less than ideal. Unfortunately i feel removing it is your only option for the time being mate.
Intel i7-6950X @ Stock for now
Corsair H105 (Push/Pull)
Asus Rampage V Extreme X99 (Bios: 3101)
32GB (4x8GB) Corsair Dominator Platinums @ 3000Mhz
512GB Samsung 950 Pro M.2
2x 256GB OCZ Vertex 4 (RAID-0)
2x EVGA Titan X Superclocks in SLI
Corsair AX1500i Titanium + Red Sleeved Cables
2x 27" Asus ROG Swift PG278Q (Surround 7680x1440 @144Hz + GSync)
Lian Li PC08 Tempered Glass Case
Logitech Z906 5.1 Surround

Thanks man

Level 8
The only way to disabled it without removing it is to plug a X8 device in the PCIE_X8_4 slot when using a 40-LANE CPU.

I would love to have the option to disable it in the UEFI.
MB: Asus Rampage V Extreme (WC loop1 rad 120x3) Bios 4101
CPU: Core i7-6950X (WC loop2 rad 120x9)
MEM: G.Skill Flare X 32GB (4x8GB) DDR4 3200MHz@CAS14/CR1
GPU: ZOTAC Trinity RTX 3090 Watercooled [double side] {PCIE_X16/X8_3 slot} (WC loop3 rad 120x9 + 140x9)
SSD: Corsair MP600 PRO XT 2To SSD M.2 NVMe w/ heatsink
HDD: 4 x 10TB Seagate IronWolf RAID 0 (WC loop1)
PSU: EVGA NEX 1500 1650W + Seasonic Fanless TX-700W
Main Screen: ASUS ROG Swift PG43UQ 4K 144Hz G-Sync/FreeSync HDR

I am using AMI BIOS 2.16.1240 (dated 2015) on an ASUS H97-PLUS motherboard. In the BIOS, I go to Advanced > PCH Storage Configuration > SATA (SATA 5,6) and M.2 Configuration.

It offers a choice among Auto, SATA, or M.2. I choose SATA > F10 > Enter. On reboot, the system returns to BIOS. It appears not to find a bootable operating system. If I change that choice from SATA to Auto or M.2, the system reboots into the Windows 10 installation on the M.2 drive.

With that item set to SATA, I boot a live Ubuntu USB drive. It boots by default; I don't have to select it in BIOS. In Ubuntu, I open the Disks program and look at the drives listed. It does not list the M.2 drive. I reboot, change SATA back to M.2, select the Ubuntu USB, and boot into Ubuntu again. Now Disks does list the M.2 drive.

This PCH Storage Configuration setting appears to offer the kind of solution the OP is looking for. Does this option not exist in other BIOSes - or did AMI remove it sometime after 2015 - or is it just hard to find?