Windows often plays the (USB) "Device Connect" and "Device Disconnect" sounds multiple times during startup for no apparent reason. And not just Win10, but also Win7 and Win8.x systems which have been patched with the latest cumulative update rollups - though I don't know exactly which specific Windows Update(s) are responsible and I haven't yet been able to discern the cause from startup logs.
I notice that the icon for Logitech Gaming Software (LGS) often appears and disappears several times during startup - it sometimes won't "finish" loading itself for a few long minutes after everything else has started up. Whatever LGS is doing or trying to do is definitely increasing the number of WinOS USB connect/disconnect sounds, all the while flickering the LEDs and transferring profile data to the (USB) keyboard/mouse much more than seems necessary.
A couple of my friends report that Corsair Utility Engine (CUE) software behaves the same way on their Win10 systems.
I also notice that USB enumeration is sometimes suspended or interrupted by misconfigured antivirus/security software. Such software usually insists on loading itself first and foremost during startup, then quick scanning memory and all active processes, and it doesn't care if it disrupts other processes (like USB drivers) which are still attempting to load. I've noticed that Avast and Norton can be pretty bad in this respect, while Kaspersky and F-Secure are pretty good. Disabling rootkit scans might correct this behaviour, although you'd be trading security for convenience.
The ASUS/Realtek HD Audio Manager software might also be involved. As in, I've never experienced this issue on computers which haven't installed this software. My Corsair CUE-using friends also report that these issues vanished after they installed PCIe audio cards, for whatever that's worth.
Disabling Legacy USB support in BIOS seems to help, at least a little. Rear-panel USB ports (especially the "dedicated" Keyboard and Mouse USB ports) seem to work more reliably than front-panel USB ports, and USB hubs/splitters can wreak all sorts of subtle havoc on USB power/signal bandwidth allocations - just plugging USB devices into different USB ports sometimes fully corrects this (and other) mysterious USB-related issues.
The sad truth is that - even in this day and age - there are many badly-coded, badly-behaved, messy, and downright awful USB drivers for USB devices new and old. They just don't fully comply with official USB standards, they can fail to work properly and (far more likely) they can introduce all sorts of conflicts with other USB devices. Manufacturers of these USB devices might have awesome hardware but they just don't know their software; sometimes you're stuck with whatever they give you, sometimes you're lucky enough to find better/working drivers made by other disgruntled customers, sometimes you're just forced to buy something else that'll work properly.
It can be a bit of an annoyance to hear these USB sounds play half a dozen times during startup, especially if they override/halt a pretty "Windows Logon" startup sound, but it's otherwise not really much of an issue. There are ways to manually configure exactly which drivers Windows loads in exactly which order, but they're too involved for most people and they tend to revert whenever new Windows Updates automatically reconfigure the operating system.
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[/Korth]