You can first make sure to have the latest Windows 10 build installed (10586.420) along with ASMedia latest USB drivers (22.214.171.124).
Then I'm not sure your issue is tied to BIOS 3101. It's rather a highlight of RVe inherent limitations when it comes to USB implementation (the poorest I have ever seen in my life). You can try the following :
1: Switch USB ports : use the USB 2.0 port for USB 2.0 legacy devices, 2: Plug at mid board some USB 3.0 header and see if that works better, 3: Reduce the number of USB devices connected to your system. It appears there are some limitations in that regards due to the number of endpoints W10 can manage (and they are way too limited), 4: Add a USB 3.1 dedicated add-on card so you have an other working controller, 5: Some will suggest to play with xHCI options in the BIOS but in my experience it never helped.
What are the USB devices you have on your system ? I mean all of them ? How many hubs (inside/out) ? It'll help us figure out if you're reaching that endpoint limit I'm talking about.