Just to reiterate, this is my SECOND B650E-E, the first one had this issue as well but I exchanged it via Amazon for another one when I started having boot instability problems. I was hoping the USB issue would be a one-off but sadly no, it is happen...
Just wanted to chime in and say I'm having this exact same issue. Bought the Strix B650E-E, top 3 USB ports (red box in the picture above) do not work, along with one on the row below. BIOS version 1413, then later 1414, no effect, still broken. Late...