Been stuck with this kind of issue.. measuring to some drastic call to install fresh copy of windows. Finally found an ASUS forum and they are discussing some issue on track pad and mouse. https://zentalk.asus.com/en/discussion/20732/asus-tuf-fx505dt...

I have the same problem. It is not actually lagging that freeze the laptop but rather the mouse is unresponsive, you can click on the icon on desktop but not on the taskbar. At first it is not really a problem because you can just press ctrl + alt + ...