I hope they fix this because I plan on buying an ASUS board for a htpc that I'm building. I might have to hold off now.

Try clearing the CMOS.http://www.asus.com/support/FAQ/1000851

Do you have intel rst installed? I had this happen and when I uninstalled the software I could finally power down.

Looks like a new bios update was released http://support.asus.com/Download.aspx?SLanguage=en&m=R9280X-DC2T-3GD5&p=9&s=10R9280X-DC2T-3GD5 VBIOS updateBIOS update to remove rare artifacting events during gaming, Please also update the Catalyst driver t...

I was thinking about buying this card, but it seems like everyone is having problems with it. Looks like a dud to me.