How about drivers? Which version are you currently using? Any other applications running in the background at the time? Does any other games suffer similar issue?
You should revert to 378.92, or, since you do not play ME: Andromeda, to an even earlier version: 378.78/378.66/378.49 (take your pick). While (because?!) all these drivers do not support Windows 10 CU, they also do not introduce a regularly occurring 'massive frameskip (20+)' type of lag in any game. At least from your description, it would seem you are experiencing the frameskip issue.
Regarding Win10CU/WDDM 2.2 and mobile lineup of GeForce 10 series cards, there are no plans (ASUS or NVIDIA) to fix this issue in the foreseeable future.
P.S. If you were to do a broader search, you will find that Dell, HP and any other laptops with GF 10 mobile series are affected.