thats because the USB sound system only goes through realteks control panel, and its not that good, if you get Razer Virtual surround sound, it'll fix that because it has an option designed for usb headphones, or if your pair of headphones needs a program to run them, like Logitech G430's do (my headphones), and that soundsystem sucks, if the bass goes up to much, they crackle, but not if you connect them to the 3.5 mm jack. they are amazing then. my solution for you would be to get razer surround sound, its very nice and if you dont really care about audio wizard anymore, its a fine substitution. but there is no way to run USB headphones off of audio wizard, its designed for the normal stereo speakers and the audio jack.