I have the same set up as you on my G750jh although different size drives. I have been putting the most played games on F as mine is c & f are the ssd split drives and d & e are the reg drive you can put a lot of stuff on the reg drive.
I tried asking ASUS tech support what the reason was for splitting the ssd drive and the reg drive but they could not seem to tell me so I guess it was for performance.
So I have BF4, D3, wow, hearthstone and ets2 on my f drive (ssd) and the less played games are on the d & e (7200 drive)
I am sorry if that sounds confusing. Hope it helps,
Happy ROG_n
Doug