Does the sub only work with ASUS apps?

[gelat]

I am not getting 2.1 sound when playing MP3 or MP4 video files with VLC or Media Player Classic

[Myk_SilentShado]

Have you set the speaker environment in Media Player Classic? is it the Home Cinema one?

[gelat]

Where do I set that?

[gelat]

and can it work with iTunes?