It's referring to the Core isolation, I'm not sure how critical it is. Apparently, it's disabled because I have virtualization disabled in the bios, so I let it disabled.
I guess Core Isolation is a new feature of windows which basically is not supported by AI Suite.
So you should either turn it off or do not rely on asus software like AI Suite.
When these Core Isolation and Memory Integrity are enabled, Windows uses hardware virtualization features to create a secure area of system memory thatÃƒÂ¢Ã¢â€šÂ¬Ã¢â€žÂ¢s isolated from the normal operating system. Windows can run system processes and security software in this secure area. This protects important operating system processes from being tampered with by anything running outside the secure area.
Even if malware is running on your PC and knows an exploit that should allow it to crack these Windows processes, the virtualization-based security is an additional layer of protection that will isolate them from attack.
As for me, I do not start AI suite at all, because it's quite useless for my purposes, I used it for overclocking after initial setup of my PC and then removed it from autostart.