Yes, if the other is labeled GTX 570 2. The lowest number is the master GPU, from what I understand. If the monitor is powered off, then it acts as if it were disconnected, so I don't think it would cause problems. Try disconnecting it physically, if you haven't already, and see if there is any kind of performance change. I would leave the PhysX settings alone, since not everything uses it, and NVIDIA's drivers evaluate the load. If you want a dedicated NVIDIA PhysX card, take a look at getting a third weaker card for that, since PhysX hits the processing power much more than the RAM. I am, unfortunately, not familiar with PhysX or with SLI from experience, I can only tell you what I have read. Maybe someone with more XP can give better advice than I.