The possibilities are endless at this point, particularly without any info about your system. I often use the inability to toggle num-lock light (if I have one) to know that an overclock config has frozen the system. It could be anything from Windows, USB drivers, overclock/electrical/unseated CPU, ram, card or one of your USB peripherals is hosed.
A little more info about your MB/OS/Game/Any OC might help narrow to things like Skylake ACPI sound card issues for instance.
In the mean-time, check your hardware - re-seat things, check for signs of physical/electrical damage, check BIOS config if you have changed it, update drivers, check the windows event log, update windows itself, then start swapping out parts, old and cheap first...