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B450-F No Display and all USB ports dead

Level 7
A bit of a strange problem but I believe I have seen a couple of posts that had similar problems. Out of the clear blue there was no signal from the video card to the monitor and none of the USB peripherals worked. The RGB lights were on and I think the fans were running as well. When I tried to force a power off it did not respond. The only way I could get the system to run was to kill the power in. This happened some months back as well. I installed a new PSU with obviously no effect. As rarely as CPUs go I am ruling that out for the time being. I suspect the motherboard but am curious if anyone else has seen such a problem.

B450_f with a Ryzen 5 2600X and 16 GB of G.Skill RAM (Flare X DDR4 3200) and a GTX 1660 GPU. The power supply is about 5 months old, an EVGA 750W Modular 80+ Gold.