Have you read any of the very good guides that are found in the Rampage forum? They may be for a different board but the settings you will need to change are the same.
Have a read and then ask questions after that way you have a better sense of what will be needed.
Rule of thumb there are only four settings that should be changed.
XMP profile for your memory if applicable and it is with your kit.
The desired multi
The amount of LLC you wish to have enabled. I suggest medium/5 as a good all round setting
and finally the vcore.
That is pretty much it.
To help us help you - please provide as much information about your system and the problem as possible.