The FCLK(Fabric Clock) and memory should be run in a 1:1 ratio in order to obtain the lowest latency, yes. On majority of UEFI builds FCLK should sync to the memory speed, however, you can sync it manually by changing the fabric clock in the UEFI (FCLK Frequency)
There is no need to change UCLK as this is the memory controller, and thus synced to the speed of the fabric.
You can check in CPUZ whether or not the FClock is scaling correctly.
13900KS / 8200MT CAS36 / ROG APEX Z790 / ROG TUF RTX 4090