For memory speeds over DDR4-3600 or if using high-density memory kits, voltages up to 1.35V (VCCSA) may be required. Some CPUs have “weak” memory controllers that require elevated voltages to maintain stability. If possible, do not venture too far from 1.35V as a maximum.
Safe Voltages (Always TENTATIVE):
System Agent (SA): 1.3v/1.25v
The first value shows voltages a pretty ballsy person can use. The voltage after the forward slash shows voltages for regular users who don't want to live on the edge.
For VCCIO/VCCSA, I do not recommend exceeding a value of 1.25v for each. I personally use a value of 1.14v for VCCIO, and 1.15v for VCCSA. Going beyond 1.25v is silly, and may potentially damage your IMC or traces on your board.
How could anyone know long term effects at this point in time
Is the ram on the Asus compatibility list for your motherboard?
Have you ran the cpu at stock default speed and tested the ram?