I have the same/similar problem. When I setup an own profile or modify the user profile, apply and save it, on next reboot it starts always with factory settings.
Also all settings are reset to factory, e.g. "Start minimized", "Apply previous settings on program startup", etc.
Before, I used GPU Tewak II without that issues. But recently that old version slowed down my PC (Win 11), especially Edge or when changing the focus to a different window, everything was stuttering for several seconds. As soon GPU Tweak II was closed, that stuttering was gone.
GPU Tweak III fixed that, but now I have that other problems. That bugs exist since the first version of GPU Tweak III and absolutely nothing has been fixed til now (actual version available is 1.5.4.9).
Many people are complaining around the world and not a single fix is made. WTF?!?
ASUS, please fix that ASAP!!!