supreme fx is a stereo amp whit mic in on it. ( if its the formula your thinking of ).
the geene is a 2 slot card and formula a 3 slot card.
so expansion on the gene is more limited than the formula board.
im not 100% shure but i think the gene is a dual slot when it comes to graphic cards. ( im not 100% shure on this so others have to back me up on this )
the onboarsd sound is good i think, you have 7.1 out on the minijacks, and stereo out ( well i havent got surround out yet that i know of ) on the SPDIF ( optical out )
ah just noticed, its the onboard intel soundchip, its newer on the F then on the G.
and if you want to hear the sound quality between them you have to take it to a test lab ( thats what i think ) to figure that out.