USB BIOS flashback is the "safest" way. Most builds can be flashed that way unless specified otherwise. There are videos on how to do it, and the MB manual should cover some of it as well. FAT32 formatted USB drive in the correct USB port. You can run the BIOS renamer tool to rename the file for you.
The other good method is EZ Flash 2 - although that requires the board is powered on.
-Raja