If the machine was running fine with a 1080ti Its not the MOBO. Yes windows installs drivers whether you like it or not and even DDU ant stop it now.
Best bet for drivers is dont install the geforcce experience and during set up choose advaned then at the bottom there is a check box for clean install the removes the old drivers. Dont freak out when your display goes black, give it a few minutes.
What card are you running? if ASUS use GPU tweak or afterburner to run the fans up to 100% and see what you get.
To be honest I almost guarantee this is a heat issue. Anything else would crash it sooner. These cards crank out some serious heat! Try removing a side panel on your machine and see if it makes a difference. Even if the GPU can take it if you are all air cooled thats some serious heat going to your CPU and RAM.
If removing the side helps then case choice or better ventilation will need to be considered or going liquid cooled.
“Two things are infinite: the universe and human stupidity, I'm not sure about the former” ~ Albert Einstein