Hi, I have been using the Rampage II Gene with Windows 7 until a month ago, so the answer is yes, it fully supports Windows 7.
But, there are no drivers or utilities for Windows 8 or 8.1. I found out when I built a new PC and used my old Rampage II Gene, RAM and Processor to build a PC for my nephew.
Someone else has started a thread about this in this forum, here:
https://rog.asus.com/forum/showthread.php?60597-Rampage-II-Gene-Sound-Drivers-amp-Sofware-for-Window... I just posted asking ASUS to help with the issue, could you post too?
cblackberry