With the brief overview out of the way, let’s get the board setup for a quick 4.3GHz overclock:
Enter UEFI and navigate to the Extreme Tweaker section:

Select the Ai Overclock Tuner option and set it to “Manual” if the memory modules being used DON’T support XMP. If the modules do support XMP, then simply select X.M.P instead.
Next set the CPU core ratio to 43X:

This sets the CPU core frequency to 4.3GHz.
If the memory modules being used do NOT feature XMP, then setting the memory frequency ratio manually is recommended. This can be done quite easily:

After that, simple press F10 to save and exit.
The final list!1) The first thing to do after applying the overclock is to complete some form of stability testing within the operating system. There are a multitude of programs available to do this, and each has its merits/shortcomings. Running a variety of different stress tests and applications is recommended to gauge system stability.
2) Check CPU and system temperatures under load are not too hot. At higher temps, the system is more prone to instability. We recommend keeping the CPU core temperature below 75C under maximum load.
3) If your cooling and CPU is up to the task, then you may wish to overclock the system further. Either way, we starting at 4.3GHz, and tuning VCore to it’s lowest stable point first. The lowest stable point is where the system can reliably pass all stability tests. I usually find the lowest Vcore the system will pass all stress tests at and then add +0.02V to Vcore for good measure.
From there, increase the CPU ratio in +1 steps, and keep an eye on how much Vcore you need to add to get the system stable. Check CPU temperatures under load also. At the point where one needs a big increase of Vcore for another 100MHz in CPU frequency, it’s wise to back down to the lower ratio and run a lower frequency. We can call this the M.E.P. – most effective point. Each CPU has one. Running an overclock at the CPU's "MEP", ensures that current consumption does not become excessive and it’s kinder to the silicon. On top of that, a paltry 100MHz increase in frequency is not worth the extra power it takes to obtain – the performance "improvement" is not worth it in my view.
We may add more info to this guide in future (as required).
Enjoy!