Depends on fully blocked the system is or maybe the impeller is slipping off the motor shaft once it gets warm?
Just some info:
I have a Thermaltake Frio Advanced (air cooling) and my system during the summer months maxs out at 115 F (just using MS Office and doing some programming) which is 43.3 C (and I have the same CPU as you)
It may be that your CPU is just running "hotter" (I have to admit that yours is a bit high) but then again it would be good for others to chime in to tell your their temps.
I assume you are running a non-overclocked system right (as if you are OCing then the temps would be higher).
Also pull a graphics card (as I think you said you have two to rule out the PSU).
Keep us posted on your progress
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For trouble-shooting tips see my blog at:
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http://thenerdbench.blogspot.com/p/bench-testing.html
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MB: Crosshair V Formula-Z • CPU: FX-8350 • GPU: Asus Matrix R9 280x • RAM: 8GB of Crucial Ballistix Tactical Tracer (1866)• PSU: Thermaltake DPS Thoughpower 750 Watt • CPU Cooler: Thermaltake Frio Advanced • Keyboard: TT Sports Challanger Ultimate • Mouse: TT Sports Black Element • Case: Thermaltake GT Level 10
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