The keyboard and mouse freezing issue can be resolved by plugging them into the USB3 ports instead of the USB2 ports. Front panel or back makes no difference. The only USB2 port without freezing is the Bios Flash port, but that's becuase it's directly connected to one of the usb host controllers rather than the usb2 hubs.
This is a problem with this motherboard. Lot's of people expereince it and don't have any idea what to do. I contacted asus support but they said to RMA it. According to a bunch of users it started in a bios update around August this year I believe.
I also find, extremely strangely, that by running the blizzard system tray app where they launch games from, prevents the freezing in the USB2 ports. Go figure.
I don't know much more about this issue. I'm using my USB3 ports and ignoring it.
Edit: Oh haha here's the post with people talking about the freezing
https://rog.asus.com/forum/showthread.php?121280-Rog-strix-b550-e-gaming&highlight=b550-e