Okay, back to crashing in F1 2016 on gaming settings. This time the game has threw up a error relating to out of memory. The hotfix driver didn't change anything, the issue still persists.
The only other games I play are Counter Strike Global Offensive, Player Unknown's Battlegrounds and Diablo 3. These seem to run okay, if not a little down on FPS. All games I play default to DX11 as I am on Windows 7. I double checked the options for each game to make sure it isn't trying to utilise something that isn't available.
With the custom fan curve the GPU temps hover around 55c whilst the GPU is under load.
My girlfriends PC is identical with the exception of PSU and she has no problem with any of the games I have being playing. At some point I am going to switch the GPU over and see if the problem persist, at least then I can rule out any other hardware being the cause.