I have nearly the same exact setup (however I also have 6 SATA drives installed) but have never had this same issue.
However, after updating the BIOS to 2204 I did have one of my 4k monitors not come on at boot, even after logging into win 11, I would have to turn it on manually even though I never turned it off. BUT the strange thing was that windows recognized that monitor even though it was turned off (or still in sleep?) as it would arrange my icons on the monitor like it was on. (like not trying to use only one monitor)
I thought I had a bad monitor or cable so I changed the cable(s) and then I went through the BIOS thinking that after the update I must have missed a setting someplace and changed some settings, I can't for the life of me remember what I changed, but "something" stopped the issue and has never happened since.
Not the same issue I realize, but it might have something to do with the cable OR possibly something you're missing in the BIOS.
Note, both my 4k's are running through display ports on my FTW on heavy high-grade cables.
PS: the only other thing I have ever had that game me a Ghost in my machine, was a bad SATA cable, you would have thought the PC was possessed by demons....all for a bad cable (that was NEW when I used it)
ASUS Maximus Z690 Apex ; intel 12900k ; ASUS Strix 4080 OC RTX ; 32G Corsair Vengeance DDR5 4800mhz XMP1 ; Samsung 980 Pro Gen4/Windows 11 Pro ; Creative AE-7 ; 2-2TB Samsung 970- Evo in DIMM.2 ; Dual LG 4k Screens ; EVGA 1300P+