FYI, there's not a whole lot of overclocking left to do on a 14900KS, they've already pushed the thing pretty much as far as it can go, there's very little headroom left. Focus on getting stable at defaults.
I don't know this for certain, but I would assume that the required signal integrity for a 14900 is more strict than 12th Gen. If you're using an AIO, make sure it isn't too tight, you'd be surprised the difference that overtightening it can make, it can and does slightly flex the CPU and socket causing the types of issues you're talking about. Get it snug by hand only, not with a screwdriver, gradually in an x pattern.
I've seen Asus tighten up the signal integrity limits in UEFI updates before.
Anyway, food for thought.
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