Connected USBs disconnect while under high gaming load using AMD 9950x3D paired with ROG X670E EXTRE

[Teletha]

After 1–2 hours of continuous high-load gaming, all of my peripherals disconnect simultaneously — including onboard audio. The audio device disappears entirely for about 5 seconds, and other peripherals like keyboard drop out for roughly 3–5 seconds before everything reconnects at once.
This issue has persisted across multiple chipset and BIOS versions. I'm currently running a stock BIOS configuration, with the only change being EXPO profiles enabled, and some other small stuff like changing aura lights and ignoring fan speed monitor for cpu fan.

this is what i managed to find in the event viewer:

USBXHCI Controller Error Encountered
Device Instance ID: PCI\VEN_1022&DEV_43F7&SUBSYS_11421B21&REV_01\6&2af91c3c&0&00600011
Failure Reason: Reset EP failed during an attempt to clear stall on control endpoint
Recovery Action: Reset
Bus Type: ParentBusTypePci
Major Version: 0x1
Minor Version: 0x10
PCI b.d.f: 105.0.0
PCI Vendor ID: 0x1022
PCI Device ID: 0x43F7
PCI Revision ID: 0x1
ACPI Vendor ID:
ACPI Device ID:
ACPI Revision ID:
Firmware Version: 0xFFFFFFFFFFFFFFFF
Instance Number: 0x2
Failure Parameter 3: 0x0
Failure Parameter 4: 0x0

[Silent_Scone]

Hi @Teletha 
EXPO is overclocking. The vSOC rail is responsible for I/O. You should consider putting the system back to Optimised Defaults and seeing if the issue persists.