I've been subject to this problem as well as I purchased a 4080 from BestBuy the other day, and I wanted to share my thought process and outcomes:
Asus B550i Strix / MSI GeForce RTX 4080 Super Ventus 3X OC / 5800x3d
I was facing numerous crashes. The first issue was crashing when booting games etc. I uninstalled the Nvidia GeForce drivers, reinstalled, everything ran great. HOWEVER, after a restart, I was back to square 1- Any game I had started up immediately crashed the system, and the PC would reboot. This would sometimes happen while doing casual web browsing etc.
I updated my bios to v.3202 as one reddit user claimed this was a fix for them - no change.
I saw this link: https://rog-forum.asus.com/t5/amd-500-400-series/b550-i-gaming-crash-with-4080-in-gen4-mode/td-p/891... and set my PCIe slot from Auto to Gen3. After this change, all games booted and everything was normal. After a restart I was back to square 1.
I enabled resizable bar - didn't see a change there either. After going into the Nvidia Control Panel - I set the "Power Management Mode" from "Normal" to "Prefer Maximum Performance". Other threads say to switch it to "Adaptive", but for 40 series cards only Normal and Prefer Maximum Performance are available as an option. After I changed this is when I started to see the "light" at the end of the tunnel.
I started 3 AAA games, Space Marine II, BF2042, and Halo Infinite. All booted, no issues. I restarted the PC, booted all 3 again, no issues. I did this process one more time, no issues.
Now, the "Prefer Max Performance" depending on what card you have may be a drawback. This will make your graphics card run at max clock speed, regardless of activity. You'll notice that your graphics card will run at high temps, even while idling with nothing running. I noticed at idle that I was running at max clock speed and around 37W. I didn't see much change in temp. Different brands and cards will react differently, this is just my experience. Now, you might want to consider changing this to a game-specific setting instead of a global setting, if that's possible. I'm going to go into the game profiles in GeForce Experience tonight and see if I can do this. If so, will the games boot if a profile is set for them individually etc.
Right now this is working for me. The moral of the story is ASUS has not released a BIOS update to combat this issue - where other B550 MBs are perfectly fine. In my opinion I do see a new B550 in my future because to jump through these hoops with hardware that ASUS deems 'compatible' is a strain when at the end of day we build these machines for different types of fun. I hope this can help some of you out. I'm curious do see if it does.
