Have seen the latest updates (KB5010414 & KB5010474) cause my mouse to lose the ability to send keystrokes mapped to the additional buttons. Removing the patches returned the mouse to normal. Error I was seeing when it was occurring in the Windows Application event log is below.
did some troubleshooting, the problem occurs with this update
2022-02 Cumulative Update Preview for .NET Framework 3.5 and 4.8 for Windows 11 for x64 (KB5010474)
and the machine was a clean install about a month ago with windows 11.
Symptoms are while in the middle of a World of Warcraft retail game the mapped buttons will no longer send mappings such as ctl+f to the game. Have to reboot the machine to get it back for a short period of time (5-15 minutes). the rest of the mouse (movement, r-click, l-click) still work normally.
Removed the update listed above, hid the update and was online for about 2 hours with no issues seen.