I’ve tried everything to get GPU Tweak III to run.

[profimaster]

Hello, today I installed the ASUS TUF Gaming Radeon™ RX 7900 XT OC Edition 16GB GDDR6 into my PC and tried to run GPU Tweak III to adjust its performance. However, the launch always ends with an error:

Faulting application name: GPU Tweak III.exe, version: 1.9.4.3, time stamp: 0x67ed0ad2
Faulting module name: TweakInterface.dll, version: 1.2.8.9, time stamp: 0x67dd09d2
Exception code: 0xc0000409
Fault offset: 0x0017e405
Faulting process id: 0x139C
Faulting application start time: 0x1DBAD626F9069FC
Faulting application path: C:\Program Files (x86)\ASUS\GPUTweakIII\GPU Tweak III.exe
Faulting module path: C:\Program Files (x86)\ASUS\GPUTweakIII\TweakInterface.dll
Report Id: 897346a7-ab07-4ebb-a41d-11659bf77f2d
Faulting package full name:
Faulting package-relative application ID:

What I’ve tried:

• Uninstalled drivers (both NVIDIA and AMD) using DDU

• Reinstalled AMD drivers multiple times (clean installation):
- Tried the latest version – 25.3.1
- Older version 24.12.1
- The newest beta version – 25.3.2

• tried different versions of GPU Tweak:
- 1.9.4.3
- 1.9.0.3
- 1.8.7.3

• Tried Windows 10 Pro, Windows 10 IoT LTSC, Windows 11 (all on completely separate disks):
- All fully updated

• Tried changing the system language to English

• Tried running Tweak as administrator, tried compatibility mode, safe mode etc.

Absolutely nothing works, and I always get the error mentioned above.

[profimaster]

I forgot to mention that I’ve tried different versions of .NET Framework and C++ Redistributable Package as well.

[profimaster]

I apologize, it is the 'ASUS TUF Gaming Radeon™ RX 9070 XT OC Edition 16GB GDDR6' card. (My AI translator changed the model on its own.)"

[profimaster]

Update: I tried a clean installation of Windows 10 on a new-empty drive with exactly the same result. I can't think of anything else to try.

[profimaster · Accepted solution]

Sorry for the spam, but after more than 14 hours of trying and testing everything possible, I finally got Tweak to launch. It seems like it won’t start unless the AMD Adrenalin installation is in "full" mode. That’s the only change I made during the last driver reinstall (which I did almost 20 times).