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Issue with ASUS GPU TweakII 2.1.8.1 and GeForce 451.48 Game Ready Driver

Mineria
Level 7
After updating to GeForce 451.48 Game Ready Driver Asus GPU Tweak II does no longer apply the last settings after booting to Windows 10 2004.
I use the external fan headers on the Strix for fans on a rad and a fan that cools my RTX 2080 Supers VRM.
User set profile is set to minimum 60% duty cycle, profile does not load after boot, apply last settings is checked in GPT Tweak II.
I even tried uninstall, stop and delete the ASUS service, delete all files from program files +(x86), program data and local app data, also removed registry entries from HKLM Software and the wow64 part in it, then rebooted and reinstalled GPU Tweak II, issue still persists.
No issue with 446.14
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