Sorry to be late to the party. I found with my card that I would get artifacts any time I put powertune to +20%
My card would produce artifacts at stock clocks with the powertune increased.
On the flip side, i can clock the gpu to 1175mhz with no problems with powertune left at +0%
The memory I can't overclock at all without getting artifacts which is a shame.
My DCII TOP memory would clock to 7000mhz or more.
I also replaced the thermal paste wich helped my temps a LOT.
Big_d4ddy: If you look at pictures of the matrix card with the cooler off of it, you can see 4 or 5 memory modules to the right of the GPU that aren't covered by the plate under the gpu heatsink. I think those modules heat up and error out when they get hot, which is why the matrix cards don't OC well (or at all) on the memory. Where, AFAIK, the DCII cards covered all the memory modules.
Almost forgot! You may want to change drivers too. When I first installed the card, I was using the latest beta drivers. After switching to the latest release (non-beta) drivers, That solved or helped most of my artifacting problems at stock speeds. This was before I replaced the thermal paste as well. If you've tried everything else and still are having problems, maybe try a few different versions of drivers to see which work best for you.