So one card works in either slot, the other card doesn't work in either slot?
Most-to-least likely causes of the fault:
- your firmware/configuration (maybe try updating to latest-greatest BIOS version, clear CMOS, replace mobo battery, etc?)
- your power supply is starting to die (no PSU lasts forever, easy to prove/disprove by testing with a robust new PSU)
- a PCIe connection (you might be able to blow out dust/etc from the mobo slot or use a contact cleaner on the card)
- a GPU card (or maybe just the cooler or some other component on the card)
- your motherboard (electrical components do eventually fail, especially if frequently overclocked or overheated)
I'm thinking the mobo battery is the culprit (a CR2032 coin cell typically lasts about 18-30 months), since you describe your system as being about 2 years old and working fine until the mysterious CF failure.
BIOS settings and SSD data (including your OS system files) can be also corrupted by sudden power loss events.
Catalyst drivers are notorious for stubbornly insisting on ninja self-updating ... and sometimes newer is not always better.
Doesn't hurt to change the battery (if it's not dying now then it probably will be soon, and 3 for $1 lol).
Manually check all relevant BIOS settings.
If you ran AI Suite or some other autoconfiguring software to get stable system settings before then run the exact same version again.
Maybe try a rollback to a previous driver configuration, Windows Restore Point, etc.
Sometimes PCIe cards (and DIMMs) need to be reseated a few times to work correctly, not so much intermittent contact as just weird and quirky.
Visually inspect your cards and mobo for signs of component damage (broken solder points, cracked PCB traces, leaky electrolytics, burnt resistors, etc) and check all the ICs to confirm chip creep hasn't pushed anything out of its socket.
Look for signs of galvanic fretting in all connectors and sockets (a type of corrosion caused when dissimilar metals are in forced contact).
That's all my ideas, lol. Good luck.
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