UEFI MemTest86 will need to be set as the first on the boot list in order to boot successfully
you will have to manually go into BIOS and change the order and set the MemTest86 stick to very first one, unless you wanna use the non-UEFI/older version
Would be nice to know what brand of wireless mouse/keyboard you are using, and what brand of the harddrives that you have.
I personally had to replace a working mushkin ssd to get rid of annoying random lag issue even if it's working fine in my other system.
Also, it is also possible to check event viewer in Windows, it might give you more info on what could be causing issue.
When you load into windows, just search for "event viewer", and select "windows logs", then "system"
warning / critical level event can often lead to instability for the system and that's what you should be looking for.
That's how I determine why I was experiencing random lag and found out the mushkin ssd was the reason behind it.
But if wired keyboard doesn't give you issue, I will just grab a wired one and be done with it 😜
or at least grab a newer set of wireless keyboard/mouse to test.
oh and, even though you said you have installed latest update via asus updater, I will still suggest that you go to the support page of your board and download the USB driver to make sure it's actually the latest.